Methylmercury impairs components of the cholinergic system in captive mink (Mustela vison) AUTHORS & AFFILIATIONS
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چکیده
The effects of methylmercury (MeHg) on components of the cholinergic system were evaluated in captive mink (Mustela vison). Cholinergic parameters were measured in brain regions (occipital cortex, cerebellum, brain stem, basal ganglia) and blood (whole blood, plasma, serum) following an 89 d exposure to MeHg at dietary concentrations of 0, 0.1, 0.5, 1, and 2 ppm (n = 12 animals per treatment). There were no effects of MeHg on brain choline acetyltransferase, acetylcholine, and choline transporter. However, significantly higher densities of muscarinic cholinergic receptors, as assessed by [H]-quinuclidinyl benzilate binding, were measured in the occipital cortex (30.2 and 39.0 % higher in the 1 and 2 ppm groups, respectively), basal ganglia (67.5 and 69.1 % higher in the 0.5 and 1 ppm groups, respectively), and brain stem (64.4 % higher in the 0.5 ppm group), compared to non-exposed controls. The calculated positive relationship between MeHg exposure and muscarinic cholinergic receptor levels in this dosing study were consistent with observations in wild mink. There were no MeHg-related effects on blood cholinesterase (ChE) activity, but ChE activity was significantly higher in the occipital cortex (17.0 % in the 1 ppm group) and basal ganglia (34.1 % in the 0.5 ppm group), compared to non-exposed controls. The parallel increases in mACh receptor levels and AChE activity following MeHg exposure highlight the autoregulatory nature of cholinergic neurotransmission. In conclusion, these laboratory data support findings from wild mink, and demonstrate that ecologically relevant exposures to MeHg (i.e., 0.5 ppm in diet) have the potential to alter the cholinergic system in specific brain regions.
منابع مشابه
Methylmercury impairs components of the cholinergic system in captive mink (Mustela vison).
The effects of methylmercury (MeHg) on components of the cholinergic system were evaluated in captive mink (Mustela vison). Cholinergic parameters were measured in brain regions (occipital cortex, cerebellum, brain stem, basal ganglia) and blood (whole blood, plasma, serum) following an 89-day exposure to MeHg at dietary concentrations of 0, 0.1, 0.5, 1, and 2 ppm (n = 12 animals per treatment)...
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تاریخ انتشار 2006